GHK-Cu (Glycyl-L-Histidyl-L-Lysine:Cu²⁺; MW 340 Da) is a naturally occurring copper-chelating tripeptide that functions as one of the most pleiotropic bioregulatory peptides known to science. It modulates the expression of >130 human genes across tissue repair, oncology, neurodegeneration, and anti-inflammatory pathways, making it an indispensable research tool for regenerative medicine, cancer biology, neuroprotection, gene expression profiling, and wound healing science.

Advanced Research Applications

1. Wound healing: Accelerates re-epithelialization by 40-50% in ex vivo models
2. Collagen synthesis: Upregulates COL1A1 expression by 200-300% in dermal fibroblasts
3. Antioxidant: SOD mimetic activity: reduces ROS by 60% in oxidative stress models
4. Hair growth: Stimulates dermal papilla cell proliferation (EC50 ~0.5 µM)
5. Anti-inflammatory: Reduces TNF-α and IL-6 by 35-45% in LPS-stimulated macrophages
6. Oncology Research: GHK-Cu is one of the most biologically intriguing research peptides in cancer biology, with documented activity across multiple tumour types
7. Gene Expression: GHK-Cu modulates >130 human genes; platforms include Affymetrix microarray, RNA-seq (Illumina), and targeted NanoString nCounter gene panels for tissue repair and oncology signatures
8. Hair Biology: Androgenic alopecia modelling: DHT-challenged DP cell systems — GHK-Cu as a copper-dependent hair follicle rescue tool for miniaturisation reversal research.

Key Technical Specifications