ATP-15 (Acetyl Tetrapeptide-15; acetyl-YPFF-NH₂; MW 613.29 Da) is a chemically stabilised μ-opioid receptor (MOR) agonist tetrapeptide engineered for research into peripheral pruritus suppression, cutaneous neuroinflammation, and epidermal barrier modulation. Its acetylated N-terminus and C-terminal amide enhance protease resistance and receptor-binding affinity, making it an ideal research-grade tool for advanced dermatopharmacology, pain and itch signalling science, and formulation development. 

Advanced Research Applications

1. Anti-itch (pruritus): Reduces histamine-induced scratching by 60-70% in ex vivo skin-nerve models
2. Anti-inflammatory: Suppresses substance P release by 50% in sensory neuron cultures (1 µM)
3. Barrier support: Increases tight junction protein (claudin-1, occludin) expression by 60%
4. Sensitive skin: Decreases TRPV1 activation by 40% in response to capsaicin
5. Atopic dermatitis model: Lowers TEWL (transepidermal water loss) by 45% after 7 days of treatment

Key Technical Specifications