Pal-GQPR (Palmitoyl Tetrapeptide-7; MW 694.9 Da) is a synthetic IgG Fc-derived lipopeptide that selectively suppresses IL-6-mediated signalling through STAT3 and NF-κB pathway inhibition. With applications spanning dermatological cytokine research, inflammatory disease modelling, immunology, wound biology, and senescence-associated secretory phenotype (SASP) suppression, Pal-GQPR is a precision research tool for cytokine modulation at the lipopeptide–membrane interface.
Advanced Research Applications:
Key Technical Specifications
|
Peptide Name |
Pal-GQPR (Palmitoyl Tetrapeptide-7) |
|
INCI / Common Name |
Palmitoyl Tetrapeptide-7 |
|
Structure |
Palmitoyl-Gly-Gln-Pro-Arg (C16 N-terminal conjugate) |
|
Molecular Weight |
694.9 Da |
|
Purity |
≥98% by RP-HPLC |
|
Primary Mechanism |
STAT3 Tyr705↓, NF-κB IκBα stabilisation, JNK/p38 MAPK↓ |
|
Primary Cytokine Targets |
IL-6↓, IL-1β↓, TNF-α↓, IL-8↓ |
|
Key Research Areas |
Cytokine Biology, Inflammatory Disease Models, SASP, Barrier |
|
Form |
Lyophilized Powder |
|
Solubility |
DMSO, ethanol; use co-solvent or surfactant (Tween-20, PEG- |
|
Storage |
−20°C, desiccated, dark; stable ≥24 months when stored |
|
CAT Number |
PS-SYN-BAR-004 |
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Pack Sizes |
10 g | 50 g | 100 g |
|
Regulatory Status |
For Research Use Only |
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